Article
Mutation analyses of KRAS exon 1 comparing three different techniques: temporal temperature gradient electrophoresis, constant denaturant capillary electrophoresis and allele specific polymerase chain reaction.
Mutation research - 17 Jul 1998
Bjørheim J, Lystad S, Lindblom A, Kressner U, Westring S, Wahlberg S, Lindmark G, Gaudernack G, Ekstrøm P, Røe J, Thilly W G, Børresen-Dale A L
Abstract excerpt
Mutations in the KRAS gene is a key event in the carcinogenesis of many human cancers and may serve as a diagnostic marker and a target for therapeutic intervention. In this study we have applied three different techniques for mutation detection of KRAS exon 1 mutations: Allele specific polymeras...
Topics
- Alleles
- Base Sequence
- Colorectal Neoplasms
- DNA Mutational Analysis
- DNA Primers
- DNA, Neoplasm
- Electrophoresis, Capillary
- Electrophoresis, Polyacrylamide Gel
- Evaluation Studies as Topic
- Exons