Article
Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1998
Inoue M, Kobayashi M, Kozaki S, Zimmer A, Ueda H
Abstract excerpt
We have studied the in vivo signaling mechanisms involved in nociceptin/orphanin FQ (Noci)-induced pain responses by using a flexor-reflex paradigm. Noci was 10,000 times more potent than substance P (SP) in eliciting flexor responses after intraplantar injection into the hind limb of mice, but t...
Topics
- Animals
- Base Sequence
- Calcium
- GTP-Binding Proteins
- Inositol 1,4,5-Trisphosphate
- Ion Transport
- Mice
- Mutation
- Nerve Endings
- Oligonucleotides, Antisense
- Opioid Peptides
- Pertussis Toxin
- Receptors, Opioid
- Substance P
- Tachykinins
- Virulence Factors, Bordetella
- Nociceptin