Induction of apoptosis by adenovirus type 5 E1A in rat cells requires a proliferation block.

Article

Induction of apoptosis by adenovirus type 5 E1A in rat cells requires a proliferation block.

Oncogene - 1 Apr 1994

Mymryk J S, Shire K, Bayley S T

Abstract excerpt

Infection with Ad5dl520EIB-, an adenovirus producing only the 243 residue E1A protein and lacking the E1B region, caused apoptosis in normal rat kidney (NRK) cells as judged by the production of nucleosomal DNA fragments. Apoptosis occurred only when the cells were growth-inhibited by cell-cell c...

Topics

Adenovirus E1A Proteins
Animals
Apoptosis
Blood
Cell Division
Cells, Cultured
Genes, Viral
Mutation
Oncogenes
Precipitin Tests
Protein Binding
Rats
Sequence Deletion

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