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Article

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

The EMBO journal - 1 Sept 1998

Parikh S S, Mol C D, Slupphaug G, Bharati S, Krokan H E, Tainer J A

Abstract excerpt

Three high-resolution crystal structures of DNA complexes with wild-type and mutant human uracil-DNA glycosylase (UDG), coupled kinetic characterizations and comparisons with the refined unbound UDG structure help resolve fundamental issues in the initiation of DNA base excision repair (BER): damage detection, nucleotide flipping versus extrahelical nucleotide capture, avoidance of apurinic/apyrimidinic (AP) site...

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Identifiers

PMID: 9724657
DOI: 10.1093/emboj/17.17.5214
PMCID: PMC1170849

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