Article
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
The EMBO journal - 1 Sept 1998
Parikh S S, Mol C D, Slupphaug G, Bharati S, Krokan H E, Tainer J A
Abstract excerpt
Three high-resolution crystal structures of DNA complexes with wild-type and mutant human uracil-DNA glycosylase (UDG), coupled kinetic characterizations and comparisons with the refined unbound UDG structure help resolve fundamental issues in the initiation of DNA base excision repair (BER): dam...
Topics
- Amino Acid Sequence
- Binding Sites
- Crystallography, X-Ray
- DNA
- DNA Glycosylases
- DNA Repair
- Humans
- Models, Genetic
- Models, Molecular
- Molecular Sequence Data
- Mutation
- N-Glycosyl Hydrolases
- Nucleic Acid Conformation
- Oligodeoxyribonucleotides