Modulation of human CACO-2 intestinal epithelial cell phenotype by protein kinase C inhibitors.

doi:10.1006/cbir.1995.1045

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Article

Modulation of human CACO-2 intestinal epithelial cell phenotype by protein kinase C inhibitors.

Cell biology international - 1 Dec 1995

Basson M D, Hong F

Abstract excerpt

Protein kinase C (PKC) isoforms are altered in colon tumors and upon exposure of intestinal mucosa to nutrients. We evaluated the effects of the PKC inhibitors staurosporine and calphostin C on human Caco-2 intestinal epithelial proliferation, motility, and differentiation. Motility was quantitat...

Topics

Caco-2 Cells
Cell Division
Cell Movement
Collagen
Enzyme Inhibitors
Humans
Microvilli
Mitomycin
Naphthalenes
Nucleic Acid Synthesis Inhibitors
Phenotype
Protein Kinase C
Staurosporine

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