Article
Proliferation modulates intestinal smooth muscle phenotype in vitro and in colitis in vivo.
American journal of physiology. Gastrointestinal and liver physiology - 1 May 2011
Nair Dileep G, Han T Y, Lourenssen S, Blennerhassett Michael G
Abstract excerpt
Intestinal inflammation causes an increased intestinal wall thickness, in part, due to the proliferation of smooth muscle cells, which impairs the contractile phenotype elsewhere. To study this, cells from the circular muscle layer of the rat colon (CSMC) were isolated and studied, both in primary culture and after extended passage, using quantitative PCR, Western blot analysis, and immunocytochemistry. By 4 days...
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