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Article

Topoisomerase II inhibition differentially modulates Caco-2 intestinal epithelial cell phenotype.

Biochemical and biophysical research communications - 6 Feb 1996

Rashid Z, Basson M D

Abstract excerpt

Caco-2 intestinal epithelial cells differentiate spontaneously after confluence when contact inhibition slows proliferation. We hypothesized that such reversible differentiation might be dependent on DNA synthesis and repair. We studied the effects of the topoisomerase II inhibitor etoposide on Caco-2 proliferation and on the differentiation markers alkaline phosphatase and dipeptidyl dipeptidase specific...

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Identifiers

PMID: 8619832
DOI: 10.1006/bbrc.1996.0185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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