Article
A protein kinase C inhibitor induces phenotypic reversion of ras-transformed pancreatic cancer cells and cooperatively blocks tumor cell proliferation with an anti- ras peptide.
Cancer chemotherapy and pharmacology - 1 Jun 2002
Way Denise, Smith Steven, Sivendran Sharmila, Chie Lyndon, Kanovsky Mecheal, Brandt-Rauf Paul W, Chung Denise L, Michl Josef, Pincus Matthew R
Abstract excerpt
PURPOSE: We have previously found that the staurosporine derivative, CGP 41 251, that has a high specificity for inhibiting protein kinase C (PKC), selectively blocks oncogenic ras-p21-induced oocyte maturation and that PKC and jun-N-terminal kinase (JNK), with which oncogenic ras-p21 directly interacts, reciprocally require each other's activation. We sought to determine whether CGP 41 251 blocks proliferation...
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