Article
Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells.
The Journal of pharmacology and experimental therapeutics - 1 Nov 2001
Liu L, Li H, Underwood T, Lloyd M, David M, Sperl G, Pamukcu R, Thompson W J
Abstract excerpt
These studies report on the activation and induction of cGMP-dependent protein kinase (PKG) by exisulind and analogs and test the hypothesis that PKG is involved in the induction of apoptosis in colon tumor cells. Exisulind and analogs are proapoptotic drugs developed as inhibitors of cGMP phosphodiesterase gene families 5 and 2 that have been shown to sustain increased cGMP in SW480 and HT29 cells. At...
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