Article
Structure and functional analysis of the MYND domain.
Journal of molecular biology - 28 Apr 2006
Spadaccini Roberta, Perrin Hélène, Bottomley Matthew J, Ansieau Stéphane, Sattler Michael
Abstract excerpt
The MYND domain (named after myeloid translocation protein 8, Nervy, and DEAF-1) is a conserved zinc binding domain. It is defined by seven conserved cysteine residues and a single histidine residue that are arranged in a C4-C2HC consensus. MYND domains exist in a large number of proteins that play important roles in development or are associated with cancers and have been shown to mediate protein-protein...
Topics
- Amino Acid Sequence
- DNA-Binding Proteins
- Humans
- Ligands
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Peptide Fragments
- Protein Binding
- Protein Folding
- Protein Structure, Tertiary