Evidence that trypanothione reductase is an essential enzyme in <i>Leishmania</i> by targeted replacement of the <i>tryA</i> gene locus

Abstract excerpt

Trypanothione reductase (TR), a flavoprotein oxidoreductase central to the unique thiol-redox system that operates in trypanosomatid protozoa, has been proposed as a potential target for the chemotherapy of trypanosomatid infections. In this study, targeted gene replacement was used to obtain evidence that TR is an essential cellular component and that its physiological function is crucial for parasite survival....

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