Down-regulation of <i>Leishmania donovani</i> trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: Effect on parasite intracellular survival

Abstract excerpt

A trans-dominant mutational strategy was used to down-regulate trypanothione reductase (TR) activity levels in Leishmania donovani, the causative agent of visceral leishmaniasis in humans. TR, regarded as an ideal drug target against trypanosomatid infections, is a homodimeric flavoprotein oxidoreductase unique to these organisms that plays a central role in the enzymatic regeneration of the thiol pool....

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