Influence of dominance, leptokurtosis and pleiotropy of deleterious mutations on quantitative genetic variation at mutation-selection balance.

Abstract excerpt

In models of maintenance of genetic variance (V (G)) it has often been assumed that mutant alleles act additively. However, experimental data show that the dominance coefficient varies among mutant alleles and those of large effect tend to be recessive. On the basis of empirical knowledge of mutations, a joint-effect model of pleiotropic and real stabilizing selection that includes dominance is constructed and...

Topics

• Genes, Dominant
• Genetic Variation
• Homozygote
• Models, Genetic
• Monte Carlo Method
• Mutation
• Population Density
• Quantitative Trait Loci
• Selection, Genetic