Article
Mechanisms of Mendelian dominance.
Clinical genetics - 1 Mar 2018
Veitia R A, Caburet S, Birchler J A
Abstract excerpt
Genetic dominance has long been considered as a qualitative reflection of interallelic interactions. Dominance arises from many multiple sources whose unifying theme is the existence of non-linear relationships between the genotypic and phenotypic values. One of the clearest examples are dominant negative mutations (DNMs) in which a defective subunit poisons a macromolecular complex. Dominance can also be due to...
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