Article
Dominance vs. epistasis: the biophysical origins and plasticity of genetic interactions within and between alleles
2022-04-04
Abstract excerpt
A central challenge in genetics, evolutionary biology and biotechnology is to understand and predict how mutations combine to alter phenotypes, including molecular activities, fitness and disease. In diploid organisms, two mutations in the same gene can either combine on the same chromosome or on different chromosomes, with interactions between the mutations quantified as epistasis and dominance, respectively. How...
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Identifiers and source
- Literature Corpus work
- f99ecd02-18d0-50a9-a145-3cad8629e721
- DOI
- 10.1101/2022.04.03.486855