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Article

Testis determination requires insulin receptor family function in mice.

Nature - 20 Nov 2003

Nef Serge, Verma-Kurvari Sunita, Merenmies Jussi, Vassalli Jean-Dominique, Efstratiadis Argiris, Accili Domenico, Parada Luis F

Abstract excerpt

In mice, gonads are formed shortly before embryonic day 10.5 by the thickening of the mesonephros and consist of somatic cells and migratory primordial germ cells. The male sex-determining process is set in motion by the sex-determining region of the Y chromosome (Sry), which triggers differentiation of the Sertoli cell lineage. In turn, Sertoli cells function as organizing centres and direct differentiation of...

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Identifiers

PMID: 14628051
DOI: 10.1038/nature02059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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