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Article

Liposomal doxorubicin extravasation controlled by phenotype-specific transport properties of tumor microenvironment and vascular barrier.

Journal of controlled release : official journal of the Controlled Release Society - 10 Nov 2015

Yokoi Kenji, Chan Diana, Kojic Milos, Milosevic Miljan, Engler David, Matsunami Rise, Tanei Tomonori, Saito Yuki, Ferrari Mauro, Ziemys Arturas

Abstract excerpt

Although nanotherapeutics can be advantageous over free chemotherapy, the benefits of drug vectors can vary from patient to patient based on differences in tumor microenvironments. Although systemic pharmacokinetics (PK) of drugs is considered as the major determinant of its efficacy in clinics, recent clinical and basic research indicates that tumor-based PK can provide better representation of therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26409121
DOI: 10.1016/j.jconrel.2015.09.044
PMCID: PMC4623952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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