Article
Restricted and individual usage of T-cell receptor beta-gene variables in nickel-induced CD4+ and CD8+ cells.
Scandinavian journal of immunology - 1 Jul 1998
Silvennoinen-Kassinen S, Karvonen J, Ikäheimo I
Abstract excerpt
Nickel allergy is manifested as contact allergic eczema elicited by delayed-type hypersensitivity, the reaction being mediated by T lymphocytes. We examined the T-cell receptor (TCR) beta-chain variable gene segment (Vbeta) use of nickel-induced CD4+ and CD8+ T cells in the peripheral blood of nickel-sensitive and nonsensitized subjects. The results show that each patient had an individual Vbeta repertoire...
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