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Article

Mononuclear cell subsets in the nickel-allergic reaction in vitro and in vivo.

The Journal of allergy and clinical immunology - 1 Apr 1992

Silvennoinen-Kassinen S, Ikäheimo I, Karvonen J, Kauppinen M, Kallioinen M

Abstract excerpt

Nickel is the major cause of metal-induced contact allergy. To understand the mechanism of its immune reaction, we studied changes in lymphocyte surface markers during nickel challenge in both allergic and healthy subjects using an in vitro nickel reaction in which the lymphocytes of allergic subjects divide when they are stimulated with nickel sulfate. The lymphocytes were labeled with monoclonal antibodies...

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Identifiers

PMID: 1532806
DOI: 10.1016/0091-6749(92)90433-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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