Article
Dominance of the BV17 element in nickel‐specific human T cell receptors relates to severity of contact sensitivity
1 Aug 1997
Abstract excerpt
Hypersensitivity to nickel (Ni) represents the most common manifestation of contact allergy in humans. The role of metal-specific T cells in this disease is well established, but the molecular interactions involved in their activation are poorly understood. We examined the T cell receptor (TCR) repertoire in T cells activated with either NiSO4 or NiSO4-treated human serum albumin from six allergic patients. For...
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