Article
Suppression of human fibrosarcoma cell growth by transcription factor, Egr-1, involves down-regulation of Bcl-2.
International journal of cancer - 11 Sept 1998
Huang R P, Fan Y, Peng A, Zeng Z L, Reed J C, Adamson E D, Boynton A L
Abstract excerpt
Previously, we showed that the transcription factor Egr-1 suppressed the proliferation of v-sis transformed NIH3T3 cells and also a number of human tumor cells. Here, we investigate the possible mechanisms responsible for this function. We show that transfected Egr-1 in human fibrosarcoma cells H...
Topics
- Blotting, Western
- DNA Probes
- DNA-Binding Proteins
- Down-Regulation
- Early Growth Response Protein 1
- Fibrosarcoma
- Gene Expression Regulation, Neoplastic
- Humans
- Immediate-Early Proteins
- Phenotype
- Proto-Oncogene Proteins c-bcl-2
- Transcription Factors
- Transfection
- Tumor Cells, Cultured