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Article

Bcl-2 Antisense Oligonucleotides (G3139) Inhibit Merkel Cell Carcinoma Growth in SCID Mice

1 Apr 2000

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10733680
DOI: 10.1046/j.1523-1747.2000.00937.x

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Related research

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Bcl-2 Antisense Oligonucleotides (G3139) Inhibit Merkel Cell Carcinoma Growth in SCID MicePMID 10733680Read ↗

Merkel Cell Carcinoma Dependence on Bcl-2 Family Members for SurvivalSemantic proximity Read ↗

Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruptionSemantic proximity Read ↗

Antisense targeting of basic fibroblast growth factor and dibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growthSemantic proximity Read ↗

Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenograftsSemantic proximity Read ↗

Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: Can they predict treatment response and clinical outcome?Semantic proximity Read ↗

Changes in gene expression induced by phosphorothioate oligodeoxynucleotides (including G3139) in PC3 prostate carcinoma cells are recapitulated at least in part by treatment with interferon-beta and -gamma.Semantic proximity Read ↗

Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cellsSemantic proximity Read ↗

Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma miceSemantic proximity Read ↗

Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cellsSemantic proximity Read ↗

504 Intratumoral delivery of Interleukin-12 DNA via in vivo electroporation leads to regression of injected and non-injected tumors in Merkel cell carcinoma: Final Results of a phase 2 studySemantic proximity Read ↗

G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner.Semantic proximity Read ↗

Why G3139 works poorly in cancer trials but might work well against HIV.Semantic proximity Read ↗

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