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Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma

7 Jan 2004

Abstract excerpt

BACKGROUND: The aim of this work was to investigate in vitro the putative role of EGR-1 in the growth of glioma cells. EGR-1 expression was examined during the early passages in vitro of 17 primary cell lines grown from 3 grade III and from 14 grade IV malignant astrocytoma explants. The explanted tumors were genetically characterized at the p53, MDM2 and INK4a/ARF loci, and fibronectin expression and growth...

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PMID: 14711380
DOI: 10.1186/1475-2867-4-1

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