Article
Direct allelic variation scanning of the yeast genome.
Science (New York, N.Y.) - 21 Aug 1998
Winzeler E A, Richards D R, Conway A R, Goldstein A L, Kalman S, McCullough M J, McCusker J H, Stevens D A, Wodicka L, Lockhart D J, Davis R W
Abstract excerpt
As more genomes are sequenced, the identification and characterization of the causes of heritable variation within a species will be increasingly important. It is demonstrated that allelic variation in any two isolates of a species can be scanned, mapped, and scored directly and efficiently without allele-specific polymerase chain reaction, without creating new strains or constructs, and without knowing the...
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