Article
High-accuracy DNA sequence variation screening by DHPLC.
BioTechniques - 1 Nov 2000
Spiegelman J I, Mindrinos M N, Oefner P J
Abstract excerpt
Genetic maps based on biallelic single-nucleotide polymorphisms amenable to microarray-based genotyping have significantly accelerated the mapping of mono- and multigenic traits in model organisms such as Saccharomyces cerevisiae and Arabidopsis thaliana. This advance needs to be matched by highly accurate, inexpensive and robust methodology for fine-structure mapping of the candidate region(s) and the eventual...
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