Article
Genome-wide allele- and strand-specific expression profiling.
Molecular systems biology - 1 Jan 2009
Gagneur Julien, Sinha Himanshu, Perocchi Fabiana, Bourgon Richard, Huber Wolfgang, Steinmetz Lars M
Abstract excerpt
Recent reports have shown that most of the genome is transcribed and that transcription frequently occurs concurrently on both DNA strands. In diploid genomes, the expression level of each allele conditions the degree to which sequence polymorphisms affect the phenotype. It is thus essential to quantify expression in an allele- and strand-specific manner. Using a custom-designed tiling array and a new...
Topics
- Alleles
- Chromosome Mapping
- DNA, Fungal
- Gene Expression
- Gene Expression Profiling
- Gene Expression Regulation, Fungal
- Genome, Fungal
- Least-Squares Analysis
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Proton-Phosphate Symporters
- Regulatory Elements, Transcriptional
- Reproducibility of Results