Article
Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray.
Science (New York, N.Y.) - 31 Mar 2006
Gresham David, Ruderfer Douglas M, Pratt Stephen C, Schacherer Joseph, Dunham Maitreya J, Botstein David, Kruglyak Leonid
Abstract excerpt
A central challenge of genomics is to detect, simply and inexpensively, all differences in sequence among the genomes of individual members of a species. We devised a system to detect all single-nucleotide differences between genomes with the use of data from a single hybridization to a whole-genome DNA microarray. This allowed us to detect a variety of spontaneous single-base pair substitutions, insertions, and...
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