Article
Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes.
Circulation - 28 Jul 1998
Kunisada K, Tone E, Fujio Y, Matsui H, Yamauchi-Takihara K, Kishimoto T
Abstract excerpt
BACKGROUND: gp130, a signal transducer of the IL-6-related cytokines, is expressed ubiquitously, including in the heart. The activation of gp130 in cardiac myocytes was reported to induce myocardial hypertrophy. The downstream side of gp130 consists of two distinct pathways in cardiac myocytes, o...
Topics
- Adenoviridae
- Animals
- Antigens, CD
- Atrial Natriuretic Factor
- Cardiomegaly
- Cytokine Receptor gp130
- DNA-Binding Proteins
- Genetic Vectors
- Growth Inhibitors
- Interleukin-6
- Leucine
- Leukemia Inhibitory Factor
- Lymphokines
- Membrane Glycoproteins
- Mice
- Mutation
- Myocardium
- Phosphorylation