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Article

Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes.

Circulation - 28 Jul 1998

Kunisada K, Tone E, Fujio Y, Matsui H, Yamauchi-Takihara K, Kishimoto T

Abstract excerpt

BACKGROUND: gp130, a signal transducer of the IL-6-related cytokines, is expressed ubiquitously, including in the heart. The activation of gp130 in cardiac myocytes was reported to induce myocardial hypertrophy. The downstream side of gp130 consists of two distinct pathways in cardiac myocytes, one a Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, the other a mitogen-activated...

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Source

Identifiers

PMID: 9711940
DOI: 10.1161/01.cir.98.4.346

Genes

STAT3
LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes.PMID 9711940Read ↗

gp130-Dependent signalling pathway is not enhanced in gp130 transgenic heart after LIF stimulation.Semantic proximity Read ↗

Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age.Semantic proximity Read ↗

gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytesSemantic proximity Read ↗

Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes.Semantic proximity Read ↗

Ral GDP dissociation stimulator and Ral GTPase are involved in myocardial hypertrophy.Semantic proximity Read ↗

Regulation of interleukin-6 cytokine responses by mitogen activated protein kinasesSemantic proximity Read ↗

Isolation and Characterization of the Human gp130 PromoterSemantic proximity Read ↗

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.Semantic proximity Read ↗

Endothelin-1 induces expression of fetal genes through the interleukin-6 family of cytokines in cardiac myocytes.Semantic proximity Read ↗

Adenovirus-mediated overexpression of caveolin-3 inhibits rat cardiomyocyte hypertrophy.Semantic proximity Read ↗

STAT3 deletion sensitizes cells to oxidative stress.Semantic proximity Read ↗

Role and relation of p70 S6 and extracellular signal-regulated kinases in the phenotypic changes of hypertrophy of cardiac myocytes.Semantic proximity Read ↗

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