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Article

Endothelin-1 induces expression of fetal genes through the interleukin-6 family of cytokines in cardiac myocytes.

FEBS letters - 30 Jul 1999

Saito S, Aikawa R, Shiojima I, Nagai R, Yazaki Y, Komuro I

Abstract excerpt

We here examined the role of the interleukin-6 (IL-6) family of cytokines in endothelin-1 (ET-1)-induced hypertrophic responses using cultured cardiac myocytes of neonatal rats. ET-1 induced expression of IL-6 and leukemia inhibitory factor (LIF) genes. ET-1-induced LIF gene expression was abolished by inhibition of protein kinase C activity. ET-1 activated the promoter of atrial natriuretic peptide and beta-type...

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Source

Identifiers

PMID: 10452539
DOI: 10.1016/s0014-5793(99)00936-9

Genes

LIF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Endothelin-1 induces expression of fetal genes through the interleukin-6 family of cytokines in cardiac myocytes.PMID 10452539Read ↗

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