Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes.

doi:10.1210/jcem.83.8.5048

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes.

The Journal of clinical endocrinology and metabolism - 1 Aug 1998

Vafiadis P, Bennett S T, Todd J A, Grabs R, Polychronakos C

Abstract excerpt

The IDDM2 susceptibility locus in type 1 diabetes corresponds to a variable number of tandem repeats (VNTR) upstream of the insulin (INS) and insulin-like growth factor 2 (IGF2) genes. Large VNTR alleles (class III) are dominantly protective, whereas small alleles (class I) are predisposing. IGF2...

Topics

Alleles
Deoxyribonucleases, Type II Site-Specific
Diabetes Mellitus, Type 1
Drug Stability
Fathers
Gene Expression
Genetic Predisposition to Disease
Humans
Insulin
Insulin-Like Growth Factor II
Leukocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes

Minisatellite Repeats

Mothers

Polymorphism, Restriction Fragment Length

RNA, Messenger

Thymus Gland

Source

Open in PubMed

Identifiers

PMID: 9709972
DOI: 10.1210/jcem.83.8.5048

Genes

IGF2
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9709972-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes.PMID 9709972Read ↗

A functional analysis of the role of IGF2 in IDDM2-encoded susceptibility to type 1 diabetes.Semantic proximity Read ↗

Imprinted and genotype-specific expression of genes at the IDDM2 locus in pancreas and leucocytes.Semantic proximity Read ↗

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.Semantic proximity Read ↗

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.Semantic proximity Read ↗

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.Semantic proximity Read ↗

Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.Semantic proximity Read ↗

IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.Semantic proximity Read ↗

The insulin-like growth factor-II receptor gene is associated with type 1 diabetes: evidence of a maternal effect.Semantic proximity Read ↗

Severe Intrauterine Growth Retardation and Atypical Diabetes Associated with a Translocation Breakpoint Disrupting Regulation of the Insulin-Like Growth Factor 2 GeneSemantic proximity Read ↗

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibilitySemantic proximity Read ↗

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus.Semantic proximity Read ↗

Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.