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Article

Secondary mutations correct fitness defects in Toxoplasma gondii with dinitroaniline resistance mutations.

Genetics - 1 Oct 2008

Ma Christopher, Tran Johnson, Li Catherine, Ganesan Lakshmi, Wood David, Morrissette Naomi

Abstract excerpt

Dinitroanilines (oryzalin, trifluralin, ethafluralin) disrupt microtubules in protozoa but not in vertebrate cells, causing selective death of intracellular Toxoplasma gondii parasites without affecting host cells. Parasites containing alpha1-tubulin point mutations are dinitroaniline resistant b...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18780736
DOI: 10.1534/genetics.108.092494
PMCID: PMC2567385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18780736-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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