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Article

Secondary mutations correct fitness defects in Toxoplasma gondii with dinitroaniline resistance mutations.

Genetics - 1 Oct 2008

Ma Christopher, Tran Johnson, Li Catherine, Ganesan Lakshmi, Wood David, Morrissette Naomi

Abstract excerpt

Dinitroanilines (oryzalin, trifluralin, ethafluralin) disrupt microtubules in protozoa but not in vertebrate cells, causing selective death of intracellular Toxoplasma gondii parasites without affecting host cells. Parasites containing alpha1-tubulin point mutations are dinitroaniline resistant but show increased rates of aberrant replication relative to wild-type parasites. T. gondii parasites bearing the F52Y...

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Identifiers

PMID: 18780736
DOI: 10.1534/genetics.108.092494
PMCID: PMC2567385

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Source receipt: pubmed, retrieved 7 Sept 2026.

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