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Article

Isolation and Functional Characterization of the PfNT1 Nucleoside Transporter Gene from Plasmodium falciparum

1 Apr 2000

Abstract excerpt

Plasmodium falciparum, the causative agent of the most lethal form of human malaria, is incapable of de novo purine synthesis, and thus, purine acquisition from the host is an indispensable nutritional requirement. This purine salvage process is initiated by the transport of preformed purines into the parasite. We have identified a gene encoding a nucleoside transporter from P. falciparum, PfNT1, and analyzed its...

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PMID: 10744765
DOI: 10.1074/jbc.275.14.10683

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