Article
Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Shioda T, Lechleider R J, Dunwoodie S L, Li H, Yahata T, de Caestecker M P, Fenner M H, Roberts A B, Isselbacher K J
Abstract excerpt
Smad4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Hetero-oligomerization of Smad4 with the pathway-restricted SMAD proteins is essential for Smad4-mediated transcription. We provi...
Topics
- 3T3 Cells
- Animals
- Apoptosis Regulatory Proteins
- Binding Sites
- DNA-Binding Proteins
- Humans
- In Vitro Techniques
- Mice
- Mutation
- Nuclear Proteins
- Protein Conformation
- Recombinant Fusion Proteins
- Saccharomyces cerevisiae