Article
Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription.
Molecular and cellular biology - 1 Dec 2003
Lin Xia, Liang Yao-Yun, Sun Baohua, Liang Min, Shi Yujiang, Brunicardi F Charles, Shi Yang, Feng Xin-Hua
Abstract excerpt
Smad6 and Smad7 are inhibitory Smads induced by transforming growth factor beta-Smad signal transduction pathways in a negative-feedback mechanism. Previously it has been thought that inhibitory Smads bind to the type I receptor and block the phosphorylation of receptor-activated Smads, thereby inhibiting the initiation of Smad signaling. Conversely, few studies have suggested the possible nuclear functions of...
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