Article
Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus.
Current biology : CB - 1 Jan 2000
Palacios E, Digilio L, McClure H M, Chen Z, Marx P A, Goldsmith M A, Grant R M
Abstract excerpt
The C-C chemokine receptor CCR5 in humans and rhesus macaques (Macaca mulatta) serves as the primary coreceptor for cellular entry by macrophagetropic strains of human immunodeficiency virus type 1 (HIV-1) and all reported strains of simian immunodeficiency virus (SIV) [1-6]. Humans homozygous for a 32 bp deletion allele of CCR5, resulting in a null phenotype, are highly resistant to infection by HIV-1 [7-9],...
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