Article
Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus.
Current biology : CB - 1 Jan 2000
Palacios E, Digilio L, McClure H M, Chen Z, Marx P A, Goldsmith M A, Grant R M
Abstract excerpt
The C-C chemokine receptor CCR5 in humans and rhesus macaques (Macaca mulatta) serves as the primary coreceptor for cellular entry by macrophagetropic strains of human immunodeficiency virus type 1 (HIV-1) and all reported strains of simian immunodeficiency virus (SIV) [1-6]. Humans homozygous fo...
Topics
- Animals
- Antigens, CD
- CD4 Antigens
- COS Cells
- Cercocebus
- Genetic Carrier Screening
- HIV-1
- Homozygote
- Humans
- Macaca mulatta
- Phenotype
- Receptors, CCR5
- Recombinant Proteins
- Sequence Deletion
- Simian Immunodeficiency Virus
- Transfection