Article
Characterization of MHC class I alleles in sooty mangabeys as a tool for evaluating cellular immunity in natural hosts of SIV infection.
Immunogenetics - 1 Aug 2015
Wang Zichun, Metcalf Benjamin, Kasheta Melissa, Kasala-Hallinan Caitlin, Tran Dollnovan, Johnson R Paul, Else James G, Karl Julie, O'Connor David, Apetrei Cristian, Kaur Amitinder
Abstract excerpt
Although immune pressure exerted by MHC class I-restricted cytotoxic T lymphocytes (CTL) are an important determinant of outcome in pathogenic HIV and SIV infection, lack of data on MHC class I genes has hampered study of its role in natural hosts with nonpathogenic SIV infection. In this study, we cloned and characterized full-length MHC class I genes derived from the cDNA library of two unrelated naturally...
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