Article
A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo.
PLoS pathogens - 26 Aug 2010
Riddick Nadeene E, Hermann Emilia A, Loftin Lamorris M, Elliott Sarah T, Wey Winston C, Cervasi Barbara, Taaffe Jessica, Engram Jessica C, Li Bing, Else James G, Li Yingying, Hahn Beatrice H, Derdeyn Cynthia A, Sodora Donald L, Apetrei Cristian, Paiardini Mirko, Silvestri Guido, Collman Ronald G
Abstract excerpt
In contrast to HIV infection in humans and SIV in macaques, SIV infection of natural hosts including sooty mangabeys (SM) is non-pathogenic despite robust virus replication. We identified a novel SM CCR5 allele containing a two base pair deletion (Δ2) encoding a truncated molecule that is not expressed on the cell surface and does not support SIV entry in vitro. The allele was present at a 26% frequency in a...
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