Article
Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host.
Nature - 3 Jan 2018
Palesch David, Bosinger Steven E, Tharp Gregory K, Vanderford Thomas H, Paiardini Mirko, Chahroudi Ann, Johnson Zachary P, Kirchhoff Frank, Hahn Beatrice H, Norgren Robert B, Patel Nirav B, Sodora Donald L, Dawoud Reem A, Stewart Caro-Beth, Seepo Sara M, Harris R Alan, Liu Yue, Raveendran Muthuswamy, Han Yi, English Adam, Thomas Gregg W C, Hahn Matthew W, Pipes Lenore, Mason Christopher E, Muzny Donna M, Gibbs Richard A, Sauter Daniel, Worley Kim, Rogers Jeffrey, Silvestri Guido
Abstract excerpt
In contrast to infections with human immunodeficiency virus (HIV) in humans and simian immunodeficiency virus (SIV) in macaques, SIV infection of a natural host, sooty mangabeys (Cercocebus atys), is non-pathogenic despite high viraemia. Here we sequenced and assembled the genome of a captive sooty mangabey. We conducted genome-wide comparative analyses of transcript assemblies from C. atys and AIDS-susceptible...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Animals
- Cell Adhesion Molecules
- Cercocebus atys
- Exons
- Female
- Frameshift Mutation