Article
Natural infection of a homozygous delta24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus.
The Journal of experimental medicine - 7 Dec 1998
Chen Z, Kwon D, Jin Z, Monard S, Telfer P, Jones M S, Lu C Y, Aguilar R F, Ho D D, Marx P A
Abstract excerpt
A homozygous 24-bp deletion (Delta24) was found in the CC chemokine receptor 5 (CCR5) of 11 out of 15 red-capped mangabeys (RCMs), Cercocebus torquatus torquatus, both in Africa and in an American zoo. The CCR5 Delta24 defect encompassed eight amino acids in frame in the fourth transmembrane regi...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cercocebus
- Genetic Predisposition to Disease
- Homozygote
- Molecular Sequence Data
- Receptors, CCR5
- Sequence Alignment
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus