Article
CD8+ T cells of Tc2 phenotype mediate a GVL effect and prevent marrow rejection.
Vox sanguinis - 1 Jan 1998
Fowler D H, Gress R E
Abstract excerpt
Donor T cells mediate both beneficial and detrimental immune reactions in the setting of allogeneic BMT (alloBMT). T cells mediate the GVL effect and prevent marrow rejection, but also induce GVHD. In an attempt to favorably influence the balance of these allogeneic responses, we have evaluated t...
Topics
- Animals
- Bone Marrow Transplantation
- Graft Rejection
- Graft vs Tumor Effect
- Humans
- Interleukin-10
- Interleukin-4
- Interleukin-5
- Lymphocyte Depletion
- Lymphokines
- Mice
- Models, Immunological
- Phenotype