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Article

CCR2 is required for CD8-induced graft-versus-host disease

22 Jul 2005

Abstract excerpt

Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (HSCT). Migration of donor-derived T cells into GVHD target organs plays a critical role in the development of GVHD and chemokines and their receptors are important molecules involved in this process. Here, we demonstrate in murine bone marrow transplantation models that the expression of the...

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Identifiers

PMID: 16037386
DOI: 10.1182/blood-2005-05-1860

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