Article
Human inhibitory receptor immunoglobulin-like transcript 2 amplifies CD11b+Gr1+ myeloid-derived suppressor cells that promote long-term survival of allografts.
Transplantation - 27 Oct 2008
Zhang Wei, Liang Siyuan, Wu Juan, Horuzsko Anatolij
Abstract excerpt
BACKGROUND: The expression of human leukocyte antigen (HLA)-G during allogeneic recognition is associated with better graft acceptance. The inhibitory receptor immunoglobulin-like transcript (ILT)-2 is expressed on activated T cells and serves to shut down T-cell activation, culminating in T-cell death, or induction of anergy. One of the potential mechanisms in the immunosuppressive accomplishment of HLA-G-ILT2...
Topics
- Adoptive Transfer
- Animals
- Antigens, CD
- CD11b Antigen
- Cell Movement
- Cell Proliferation
- Cells, Cultured
- Graft Rejection
- Graft Survival
- HLA Antigens
- HLA-G Antigens