Article
CD4+CD25+ T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes, suggesting separate pathways of activation by Th1 and Th2 responses.
Blood - 8 Jan 2009
Verma Nirupama D, Plain Karren M, Nomura Masaru, Tran Giang T, Robinson Catherine, Boyd Rochelle, Hodgkinson Suzanne J, Hall Bruce M
Abstract excerpt
CD4(+)CD25(+)Foxp3(+) T cells are regulatory/suppressor cells (Tregs) that include non-antigen (Ag)-specific as well as Ag-specific Tregs. How non-Ag-specific naive CD4(+)CD25(+) Treg develop into specific Tregs is unknown. Here, we generated adaptive Tregs by culture of naive CD4(+)CD25(+)Foxp3(+) T cells with allo-Ag and either interleukin-2 (IL-2) or IL-4. Within days, IL-2 enhanced interferon-gamma receptor...
Topics
- Animals
- Caspase 1
- Cytokines
- Graft Rejection
- Heart Transplantation
- Interleukin-2
- Isoantigens
- Lymphocyte Activation
- Myocardium
- Phenotype