[Characterization of ligand-dependent transactivation regions of the human vitamin D receptor].

Article

[Characterization of ligand-dependent transactivation regions of the human vitamin D receptor].

Nihon rinsho. Japanese journal of clinical medicine - 1 Jul 1998

Nakajima S

Abstract excerpt

The 1,25-dihydroxyvitamin D receptor (VDR) belongs to the nuclear hormone receptor family. Mutational analysis revealed that the carboxyl-terminal region between leucine-417 and glutamic acid-420 of the human VDR is essential for the ligand-dependent transactivation. Mutant VDR at this AF-2 regio...

Topics

Gene Expression Regulation
Humans
Ligands
Mutation
Nuclear Proteins
Protein Binding
Receptors, Calcitriol
Transcriptional Activation

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