Article
The C-terminal region of the vitamin D receptor is essential to form a complex with a receptor auxiliary factor required for high affinity binding to the vitamin D-responsive element.
Molecular endocrinology (Baltimore, Md.) - 1 Feb 1994
Nakajima S, Hsieh J C, MacDonald P N, Galligan M A, Haussler C A, Whitfield G K, Haussler M R
Abstract excerpt
The human vitamin D receptor (hVDR) requires another nuclear protein(s), designated receptor auxiliary factor (RAF), for optimal binding to the vitamin D-responsive element (VDRE). To determine the region in hVDR required to form a heterodimer with RAF on the VDRE, mutant hVDR cDNAs were constructed by site-directed mutagenesis and transfected into COS-7 cells. A truncated hVDR, lacking 25 C-terminal amino acids...
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