Article
Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2).
Molecular endocrinology (Baltimore, Md.) - 1 Aug 1998
Berrevoets C A, Doesburg P, Steketee K, Trapman J, Brinkmann A O
Abstract excerpt
Previous studies in yeast and mammalian cells showed a functional interaction between the amino-terminal domain and the carboxy-terminal, ligand-binding domain (LBD) of the human androgen receptor (AR). In the present study, the AR subdomains involved in this in vivo interaction were determined i...
Topics
- Animals
- Binding Sites
- CHO Cells
- Cricetinae
- Dimerization
- Humans
- Luciferases
- Mutation
- Nuclear Receptor Coactivator 2
- Promoter Regions, Genetic
- Receptors, Androgen
- Recombinant Proteins
- Saccharomyces cerevisiae
- Transcription Factors
- beta-Galactosidase