Decreased bone mass and bone elasticity in mice lacking the transforming growth factor-beta1 gene.

doi:10.1016/s8756-3282(98)00078-7

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Article

Decreased bone mass and bone elasticity in mice lacking the transforming growth factor-beta1 gene.

Bone - 1 Aug 1998

Geiser A G, Zeng Q Q, Sato M, Helvering L M, Hirano T, Turner C H

Abstract excerpt

Transforming growth factor-beta1 (TGF-beta1) knockout (TGF-beta1(-/-)) mice were used to investigate the role of TGF-beta1 in postnatal bone development. Volumetric bone mineral density (BMD) and mineral content (BMC) in these mice and in their normal (TGF-beta1(+/+)) and heterozygous (TGF-beta1(...

Topics

Animals
Bone Density
Bone Development
Bone Marrow Cells
Cells, Cultured
Elasticity
Genotype
Growth Plate
Mice
Mice, Knockout
RNA
Tibia
Tomography, X-Ray Computed
Transforming Growth Factor beta

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