Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations.

doi:10.1093/jnci/90.15.1138

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Article

Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations.

Journal of the National Cancer Institute - 5 Aug 1998

Lakhani S R, Jacquemier J, Sloane J P, Gusterson B A, Anderson T J, van de Vijver M J, Farid L M, Venter D, Antoniou A, Storfer-Isser A, Smyth E, Steel C M, Haites N, Scott R J, Goldgar D, Neuhausen S, Daly P A, Ormiston W, McManus R, Scherneck S, Ponder B A, Ford D, Peto J, Stoppa-Lyonnet D, Bignon Y J, Struewing J P, Spurr N K, Bishop D T, Klijn J G, Devilee P, Cornelisse C J, Lasset C, Lenoir G, Barkardottir R B, Egilsson V, Hamann U, Chang-Claude J, Sobol H, Weber B, Stratton M R, Easton D F

Abstract excerpt

BACKGROUND: We have previously demonstrated that breast cancers associated with inherited BRCA1 and BRCA2 gene mutations differ from each other in their histopathologic appearances and that each of these types differs from breast cancers in patients unselected for family history (i.e., sporadic cancers). We have now conducted a more detailed examination of cytologic and architectural features of these tumors....

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Identifiers

PMID: 9701363
DOI: 10.1093/jnci/90.15.1138

Genes

BRCA1
BRCA2

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