The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2.

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The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2000

Lakhani S R, Gusterson B A, Jacquemier J, Sloane J P, Anderson T J, van de Vijver M J, Venter D, Freeman A, Antoniou A, McGuffog L, Smyth E, Steel C M, Haites N, Scott R J, Goldgar D, Neuhausen S, Daly P A, Ormiston W, McManus R, Scherneck S, Ponder B A, Futreal P A, Peto J, Stoppa-Lyonnet D, Bignon Y J, Stratton M R

Abstract excerpt

Breast cancers arising in carriers of mutations in the breast cancer susceptibility genes, BRCA1 and BRCA2, differ histologically from each other and from breast cancers unselected for a family history. However, a substantial proportion of families with multiple cases of breast cancer is not attributable to these two genes (non-BRCA1/2 families). We have now characterized the pathology of 82 breast cancers from...

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PMID: 10741697

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BRCA1
BRCA2

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