Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers.

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Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2003

Palacios José, Honrado Emiliano, Osorio Ana, Cazorla Alicia, Sarrió David, Barroso Alicia, Rodríguez Sandra, Cigudosa Juan C, Diez Orland, Alonso Carmen, Lerma Enrique, Sánchez Lydia, Rivas Carmen, Benítez Javier

Abstract excerpt

PURPOSE: Most familial breast cancers are not associated with BRCA1 or BRCA2 germ-line mutations. Therefore, it is of major importance to define the morphological, immunohistochemical, and molecular features of this group of tumors to improve genetic testing and also gain further insight into the biological characteristics of tumors. EXPERIMENTAL DESIGN: We evaluated the morphological characteristics of 37 tumors...

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PMID: 14506147

Genes

BRCA1
BRCA2
MYC
BCL2

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